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It's a plausible-sounding theory whose major defect is the absence of supporting evidence.
Another major defect is the willingness of political authorities to replace manual police controls by adopting an ASE system to enforce the speed limits.
In regards to the amnioserosa itself, the authors find that this structure has disrupted zonula adherens and, through a series of rescue experiments, conclude that the major defect is due to excessive Rho-mediated amnioserosa contractions.
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The second major defect was in cell migration where the sec7 - cells were slower and less persistent.
Just as shown by immunofluorescence, the SEM images indicated that the major defect was in the ciliated cells (Fig. 7A,B).
Concerning the recovery of SVs after the stimulus (striped sectors), the major defect was observed in the reformation of labeled SVs from bulk endosomes (black stripes), this value was extrapolated (as for Figure 2I ) by subtracting from the total striped area the fraction of SVs that become labeled when CTX-HRP was added only after the stimulus.
For minor defects membranes were used (lyophilized dura or alloplastic dura mater), whereas major defects were repaired with bone grafts (autografts, heterografts, or bone substitute material).
David Healy, professor of psychiatry in Bangor, Wales, who gave evidence in the Kilker case, said that at 4%, the rate of birth defects was double the normal rate, while the rate of major defects was 2% compared with 1%.
These and other major defects were first exposed by safety advocates who petitioned the government and by reporters in the tradition of Bob Irvin of The Detroit News, who wrote over 35 articles on Chevrolet engine mounts until General Motors agreed to recall 6.7 million vehicles in 1971.
In our view, processing with Freesurfer can also be recommended in smaller samples provided each segmented structure is carefully screened and major defects are manually corrected.
Hippocampi with major defects were excluded from further analyses as they were few, could easily be identified, and would necessitate manual editing in order to be analysed, which was not the focus of the present study.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com