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One major current knowledge gap in understanding the circadian control is the regulation of peripheral clocks (21).
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The paucity of data on appropriate triage of patients for surgery has been identified as a major gap in current knowledge and is suggested as a priority for future studies [ 68].
It will provide opportunities for studying translational selection and its association with alternative splicing of genes in these species that constitutes a major gap in current knowledge of mosquito genomics (Severson and Behura 2012).
We summarize what is known about each of these 15 categories, identify major gaps in our current knowledge, and recommend the next steps required for better understanding of trends in biodiversity.
A major portion of our current knowledge about gene function in mammals is derived from the phenotypes of mouse strains with targeted or random gene inactivation [ 9].
A major contribution to our current knowledge about T4SS nanomachineries in bacteria came from resolution of crystal structures of the T4SS-core from plasmid pKM101 [ 45, 55].
The lack of a robust phylogeny for the specialized predators within the dorylomorph ants has been recognized as a major gap in our current knowledge of higher-level ant diversification [ 1].
The extent of the involvement of FBMs in GPCRs, the superfamily of cell surface receptors for conducting FLNa-mediated cytoskeletal signaling, is a major gap in the current knowledge base.
A major gap in the current knowledge base concerning exposure assessment and human activity patterns derives from the cross-sectional or short-term nature of most population-based exposure datasets.
While some studies have attempted to establish appropriate WC cutoffs for Latino women based on prevalent metabolic risk factors and diabetes, future studies are needed to describe abdominal fat distribution at various WC cut points and determine which thresholds predict incident diabetes, a major gap in our current knowledge (19).
In this consensus document we summarize the current knowledge on major asthma, rhinitis, and atopic dermatitis endotypes under the auspices of the PRACTALL collaboration platform.
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