Sentence examples for major conformational changes from inspiring English sources

In some cases, the binding of a ligand can lead to major conformational changes, resulting in significant different protein conformations.

About a decade ago, the structure elucidation of the HCV-polymerase led to the assumption that substrate/template binding and double-stranded RNA product formation are necessarily accommodated by major conformational changes of the enzyme to an open conformation.

This RMSD indicates that the H3K4me0 peptide binding does not induce major conformational changes to the backbone of PHD1KDM5B.

The CBS domain pair dimer (CBS module) displays an unusual head-to-tail configuration and nucleotide binding triggers no major conformational changes in the magnesium-free state.

Thus, phosphotyrosyl ligand binding induced major conformational changes in the SH3-SH2 and βB-βC linkers, part of βD, and βD-βE linker region, thereby allowing modulating kinase activity through domain interactions.

Since the conformation of the extracellular matrix protein fibronectin (Fn) is highly sensitive to local ion concentrations, major conformational changes can be observed by FRET, as Fn senses and responds to varying local ionic conditions.

No major conformational change in CD4 accompanies binding to ibalizumab.

For importers, this major conformational change directly results in substrate transport from COut to CIn.

Clathrin AP2 has been found to undergo a major conformational change upon its recruitment from the cytosol to membrane (Jackson et al., 2010).

In both simplified importer and exporter models discussed above, we made the assumption that ΔGD s) is associated with the major conformational change occurring while substrate is carried across.

Structural study on clathrin AP1 also suggests that it undergoes a major conformational change upon membrane recruitment (Ren et al., 2013).