Sentence examples for major conformational alteration from inspiring English sources
The major conformational alteration observed during the simulations is a narrowing of the N-terminal region of the peptide-binding site (Fig. 2A).
The density was of sufficient quality to assess that the overall fold of the W438 variant is identical to that of the R438 wild-type form, indicating that the R438W substitution does not result in a major conformational alteration (the rmsd between the R and W structures is 0.509 for 324 C-a atoms).
Due to the complex interlaced architecture of fibrillar extracellular matrix, a large range of conformations is seen in native extracellular matrix and often, major conformational alterations are seen at distances along a extracellular matrix fibril of one micron or shorter [35].
No major conformational change in CD4 accompanies binding to ibalizumab.
For importers, this major conformational change directly results in substrate transport from COut to CIn.
However on Mg-ATP binding, a major conformational change of helix-α6 is observed in both motors.
During apoptosis, Bak and Bax permeabilize the mitochondrial outer membrane by undergoing major conformational change and oligomerization.
This major conformational change is probably the reason why binding of the cofactor is a relatively slow process (30).
In some cases, the binding of a ligand can lead to major conformational changes, resulting in significant different protein conformations.
Background: Conformational alteration and fibril formation of proteins have a key role in a variety of amyloid diseases.
Thus, our findings on the conformational alteration of SHP-2 in a solution interrupted system furthers our understanding of allosterism.
