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Because selectivity is the major concern, both ligand-based and protein-based pharmacophore methodologies were used to identity potent and selective MMP-13 inhibitors.
The prevalence of increasingly resistant organisms is a major concern, both for achieving therapeutic success and because of broader cross-resistance implications [ 27].
Resistance to antimicrobial agents has become a major concern both for human health and in veterinary medicine.
The public discussion following a large number of scientific articles related to overdiagnosis in national mammographic screening programs for breast cancer has become a major concern both for national screening programs and women deciding to participate.
The issue of multiple testing might therefore not be a major concern both due to the descriptive nature of the study, and due to the fact that many of the p-values appear in nice patterns, not randomly.
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Some symptoms were of very short duration (lasting only seconds or at most a few minutes), while other lasted for several hours (ptosis, sensation of leg heaviness); both short- and longer-lived symptoms could be of major concern to both patient and physician.
Recruitment of both 'high-risk' and 'low-risk' drinkers will have the additional benefit of addressing a major concern among both young people and parents that participation in a trial of this nature may suggest that the participant is drinking at a level that warrants concern and intervention.
With 50 million beneficiaries, Medicare is a major concern for both parties.
"The major concern of both parties is to have domination in the area," a foreign diplomat said.
Since then, power management on multicore architectures has received increasing attention [12], and power consumption has become a major concern for both hardware and software design for multicore.
The industrial discharge to the water bodies is a major concern to both human and other living things as it directly affects their health and food sources.
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