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The presence of a high-dimensional stochastic input domain with discontinuities poses major computational challenges in analyzing and quantifying the effects of the uncertainties in a physical system.
The two major computational challenges associated with custom-made arrays are design and analysis.
The major computational challenges are in the generation of p-values for MDR through permutation tests but this is not the major focus of our work.
While it is not complicated to obtain the OR, examination of high-order DDI effects on myopathy faces major computational challenges due to the combinational escalation.
The major computational challenges from the proposed A-MDR and other approach in MDR framework are in the generation of p-values for MDR.
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Thus, the application of NMPC to processes that need fast feedback poses a major computational challenge.
Multiscale simulations of fluids such as blood represent a major computational challenge of coupling the disparate spatiotemporal scales between molecular and macroscopic transport phenomena characterizing such complex fluids.
The major computational challenge posed in this method is related to finding the design point excitation for the threshold corresponding to the failure of the nonlinear system.
The major computational challenge, when using frequency domain linearised computational fluid dynamics in the analysis of aeroelastic problems such as aircraft flutter, gust response or shock buffet, are the excessive memory and CPU time requirements to solve the large sparse linear systems of equations.
A major computational challenge in the genomic era is annotating structure/function to the vast quantities of sequence information that is now available.
A major computational challenge is to analyze all signals simultaneously to provide the best estimate of the user's desired movement.
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