In the GWDF group, 13 patients (7.6%) had a major complication, compared with 9 patients (5.3%) in the CBR group.
Interestingly, the bridging therapy did not reduce cardiovascular events but led to higher rates of major bleeding complications compared with no bridging.
13 For these reasons, we hypothesise that the MIO McKeown procedure may result in a significant decrease in major respiratory complications compared with the open McKeown procedure for oesophageal SCC, without comprising the oncologic clearance.
In our opinion, the main reason for the increase in ESIN is its good immediate outcome and the lack of major short-term complications compared with nonoperative treatment (Kay et al. 1986, Salonen et al. 2012, Sinikumpu et al. 2012a, Colaris et al. 2013).
In addition, we found that participants requiring Home F/U were more likely to have sustained 2 or more major complications when compared to Routine F/U participants (p=0.05) (Table 6).
No shrinkage was an independent risk factor for late complications compared with major shrinkage (hazard ratio (HR) 3·11; P < 0·001).
There was no evidence that PDT was associated with an overall increase in the rate of bleeding, other major complications or long-term complications, compared to ST.
Further, a subgroup analysis of 30 cases with osteoporosis demonstrated that medial support restoration led to significantly less major bone- and fracture-related complications compared to medial support loss.
A major downside are increased rates of wound complications compared to postoperative RT.
