In fact, no deaths or major complications due to the procedure were reported in the registry.
Subjects with major complications due to diabetes (e.g. major cardiovascular disease, renal insufficiency, blindness, amputations) were excluded.
Although we did not observe any major complications due to heparin use, patients with a risk of bleeding can be managed without anticoagulation [ 1, 22, 23].
For these reasons, no major complications due to the PCSNB block procedure were observed in any of our patients intra-postoperatively.
Furthermore, subjects with major complications due to diabetes (e.g. major cardiovascular, renal or vascular disease, and blindness) and subjects who used any kind of antidepressants were also excluded.
One patient refused to participate in follow-up, one patient had major complications due to chemotherapy and could not participate in follow-up, one patient refused follow-up after 3 months, and one patient was excluded from follow-up because she refused radiotherapy.
3 Sometimes haemothorax can be a major complication not due to acupuncture treatment but as a result of bleeding from insertion of a thoracic catheter (the differential diagnosis can be made by measuring the Hct and Hb levels of the pleural effusion).
The major complications are due to possible repeats within aligned sequence, sequence homology/identity around breakpoints and, the often complex nature of SVs, where, for instance, a deletion/insertion is accompanied by smaller insertion/deletion.
Other gynecologists, however, are reserved due to the higher major complication rate, and their concerns have been affirmed in a recent report of the Dutch Health Care Inspectorate [8].
