Sentence examples for major codons are from inspiring English sources

These findings support the hypothesis that major codons are used preferentially in genes coding for proteins required by the cell in large quantities (see [ 10] and references therein).

There is limited experimental evidence that major codons are translationally superior [ 11- 14], but empirical data can be explained well in this framework.

Beginning with pioneering work in the 1980s, it has been demonstrated convincingly that major codons are more accurately and more efficiently recognized by the most abundant tRNA species [ 3- 10].

In highly expressed genes, codons with abundant or perfectly matching tRNAs (major codons) are apparently preferred over codons are translated by rare or "wobbling" tRNAs (minor codons) [ 29, 30].

In highly biased genes, major codons are more likely to be used at evolutionary conserved sites, while minor codons are more likely to be used at evolutionary variable sites.

Major codons were identified by estimating the relative frequency of each synonymous codon encoding a particular amino acid across our set of third chromosome genes.

If codon bias results from an effort to increase translational accuracy, the use of major codons is hypothesized to be favored at important and evolutionary conserved amino acid sites (Akashi 1994).

Preferential use of a major codon was observed for all amino acids (Table 3).

By property 1, and the assumed relation between tRNA gene copy numbers and cellular tRNA abundance, a major codon is assumed to have a translational advantage over non-major codons, as it is assumed to have more tRNAs.

Figure 1 contains bar graphs describing the relation between breadth of expression and RMCU for the amino acids in Group A. (It is evident from Table 1 that for 7 out of the 8 amino acids from group A, the RSCU of the major codon is in positive relation with breath of expression).

The relative frequencies of major and minor codons are similar to that observed by Akashi and Schaeffer (1997), where only 22 genes in D. pseudoobscura were analyzed (P≈1,r=.992).