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Clinically, there was no major toxicity except for mild fever, and no major clinical response towards vaccination was observed.
The secondary endpoints included major clinical response (MCR), partial clinical response (PCR) and relapse.
In addition, the proportions of patients achieving a major clinical response at 1 year were analyzed.
Primary efficacy endpoints were major clinical response (MCR) and partial clinical response (PCR) assessed during the 12-month study period.
Treatment-to-target would therefore seem a rational approach to take in an attempt to improve the major clinical response.
In addition, not all AS patients achieve remission or a major clinical response to NSAIDs and TNF-α blockers [ 21].
Similar(39)
Response to colchicine represents a major clinical diagnostic criterion, with over 90% of patients experiencing amelioration of symptoms, while on treatment [ 4].
However, for the first time after decades of basic research and clinical investigation, new drugs have produced major clinical responses.
Seven patients stabilized, but no major clinical responses were seen.
These findings have important implications for future clinical trials of EGFR inhibitors in colorectal cancer, as they imply that these agents are able to disrupt activation of ERK signalling, but that in itself is insufficient to produce major clinical responses.
On an intention to treat analysis of the entire 41 patient population, major clinical responses were observed in 22 patients for an overall RR of 54% (CI, 45 75%) (Table 3).
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