This co-occurrence raises two major clinical questions: whether there are underlying common environmental, genetic and neurobiological ethiopathological factors and what is their impact on clinical care.
One of the major clinical questions is how to identify those patients who may be able to avoid adjuvant chemotherapy because of their low risk of recurrence.
The results of ACCORD, ADVANCE, and VADT highlight the critical need for randomized controlled trials with meaningful clinical outcomes, such as in these trials, to help answer major clinical questions.
However, the major clinical questions confronting the nephrologist in considering the diagnosis of ischemic nephropathy include, "Which clinical or laboratory features are most useful in its detection?" The finding that increased RI of renal arteries is significantly correlated with albuminuria would provide a clue to study the clinical prognosis of less severe but long-term ischemic nephropathy.
Symptom substitution was a major scientific and clinical question about a half century ago that was abandoned rather than answered partly because it did not seem to occur and partly because perceived methodological problems impeded empirical research.
An unanswered question of major clinical interest is whether this will improve or impede drug delivery to the brain.
Safety of the selective serotonin reuptake inhibitors (SSRIs) during pregnancy is a question of major clinical importance as up to 6% of pregnant women are reported to use SSRIs [ 1].
It is divided into 4 sections, each with a questions and answers section: General, Etiologic Agents, Select Major Clinical Syndromes, and Special Hosts and Situations.
Meanwhile, what major factors affect individual medication adherence behavior among people with chronic conditions is an essential research and clinical question to be investigated.
