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Leishmaniasis has traditionally been classified into three major clinical forms: visceral leishmaniasis (VL), cutaneous leishmaniasis (CL) and mucocutaneous leishmaniasis (MCL) which differs in immunopathologies and degree of morbidity and mortality.
Two major clinical forms of dengue illness involve the mild form of dengue fever and severe form mostly characterized by plasma leakage with or without haemorrhage [ 2].
The disease can take, even within a given batch of animals, three major clinical forms, namely peracute, acute or chronic disease [ 2].
Although it is generally accepted that major clinical forms of ATL may be caused by specific Leishmania species, the relationship between Leishmania zymodemes and clinical presentation remains unclear [ 4].
Inflammatory bowel disease (IBD) is an immune-mediated, chronic disorder characterized by remittent or progressive inflammation that may affect the entire gastrointestinal tract, with two major clinical forms: Crohn's disease (CD) and ulcerative colitis (UC) [ 1].
There are two major clinical forms of DEDs: the deficient aqueous tear production type (due to lacrimal gland dysfunction) and the increased evaporative loss type (due to meibomian gland disorder), but combinations of the two forms are usually seen in clinical practice [ 2, 3, 7, 8].
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Therefore, restoration of β-cell mass is of major clinical significance in both forms of diabetes.
Control of the inflammatory status of trauma patients forms a major clinical problem since the inflammatory cascade is already ongoing upon presentation.
Bacillus anthracis is a gram-positive, spore-forming, rod-shaped bacterium that causes three distinct clinical forms of anthrax depending on the major routes of infection: inhalational, cutaneous, and gastrointestinal [1].
L. major was isolated and clearly identified in three clinical forms (wet, dry, and mixed ulcers), while we expected to observe only in wet lesions.
Currently, our incomplete understanding of the adhesion mechanisms important in the most life-threatening clinical forms of malaria is a major obstacle to the development of adjunctive therapies.
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