Sentence examples for major clinical challenges from inspiring English sources

Sensitization to human leukocyte antigens (HLAs) remains one of the major clinical challenges for successful kidney transplantation.

Despite three approved therapeutic options, the cross-resistant BCR-ABLT315I mutation and compound mutants selected on sequential inhibitor therapy remain major clinical challenges.

One of the major clinical challenges in STS management is successfully interdicting their enhanced propensity for local recurrence.

One of the major clinical challenges, in orthopedic and reconstructive surgeries, is filling large osseous defects [ 1, 2].

Despite the growing knowledge on the mechanisms of fracture healing, delayed healing and non-union formation remain major clinical challenges.

Despite the introduction of many anti-hyperglycemic agents from natural and synthetic sources, diabetes and its secondary complications continue to be a major clinical challenges.

Metastasis is a major clinical challenge for cancer treatment.

Osteoporotic fracture (OPF) remains a major clinical challenge for skeletal regeneration.

Diabetic foot ulcers (DFUs) represent a major clinical challenge in the ageing population.

The spread of cancer cells to distant organs represents a major clinical challenge in the treatment of cancer.

The assessment, treatment and management of aggressive youth represent a major clinical challenge facing pediatric mental health professionals today.