Sentence examples for major checkpoint signalling from inspiring English sources

We report a novel finding that NEU causes activation of major checkpoint signalling kinases, Chk1 and Chk2.

NEU causes damage in mammalian cells in the form of double strand and single strand breaks that temporally activate the major checkpoint signalling kinases without the occurrence of cross-talk between the pathways.

Together, these studies have unveiled a tight link between FANCM and S-phase checkpoint signalling.

Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signalling.

By showing that Aurora B might contribute to checkpoint signalling independently of error correction, we provide the basis for a better molecular understanding of the checkpoint sensory apparatus.

However, SCE becomes a major mechanism to repair DNA DSBs when cells with a defective checkpoint signaling are challenged by replication stress.

Reduced Mps1 kinase activity allows weakened mitotic checkpoint signaling as well as lagging chromosomes at anaphase, two major defects suggested to contribute to CIN in tumor cells [5], [10].

Cells use special proteins and checkpoint signaling systems to ensure that the cell cycle progresses properly.

Second, BubR1 activates mitotic checkpoint signaling cascades by binding to the centromere-associated protein E, a microtubule motor protein.

The highly conserved Ndc80 kinetochore complex makes direct contacts with the microtubule and is essential for spindle checkpoint signaling.

Tel1 is a kinase involved in telomere maintenance and checkpoint signaling.