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His design drew fierce public criticism, major changes were called for, costs spiralled, and then finally the scheme was shelved in 2004.
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These changes are called "Commands".
Radical change was called for.
Finding instantaneous change is called differentiation.
The major changes were in receptor pharmacology, with decreased potentiation in response to acute ethanol and diazepam and increased effects of a compound called RO15-4513.
Major changes were proposed.
No major changes were made.
No major changes were necessary.
Facebook's privacy conference call just ended, and it's clear some major changes are going to be coming to the social network soon.
Major changes are on the horizon.
In the 1960s a major change was pioneered by Iowa Beef Processors, called "boxed beef".
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