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"major changes to" is correct and usable in written English.
You can use this phrase when you want to talk about significant modifications that have been made to something. For example: "The organization has recently implemented major changes to its recruitment process."
Exact(60)
Major changes to student loans.
Otherwise, no real major changes to report.
He said no major changes to other reforms were expected.
Dominik effects a couple of major changes to Higgins's text.
Last week, major changes to the school curriculum were announced.
It would require major changes to the tax code.
JASTA makes two major changes to existing federal law.
There are three major changes to Facebook's UI.
Electricity has brought major changes to village life.
The Guardian has disclosed that ministers were preparing to make major changes to the proposed bill.
"I don't plan to make any major changes to the organization," Mr. Cardwell said.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com