Sentence examples for major challenges limit from inspiring English sources

However, some major challenges limit their translation to the clinic.

However, pervasive targeting of sequences that closely resemble the intended target has remained a major challenge, limiting the reliability and interpretation of RGN activity and the range of possible applications.

However, the major challenge limiting current therapy is the rapid evolution of drug resistance resulting from the high mutation rate caused by the absence of a proofreading function in HIV reverse transcriptase.

(Policy maker) Despite the high benefits of PMTCT, major implementation challenges limit the scale-up of the programs beyond the 50percentt coverage.

Soil salinity-alkalinity is one of the major environmental challenges limiting crop productivity globally.

Nevertheless, the low hydroxide conductivity remains major challenge that limits the development and application of APEFC.

However, the oxidation resistance of Cu-based electrical contact materials at high temperatures is still the major challenge that limits their applications.

However, low alcohol yield (<25% w/w), low reactor productivity (approximately 0.3 g · L-1 · h-1), and high energy-consumption and water usage due to low solvent titer (approximately 20 g/L) are major challenges of conventional ABE fermentation, limiting the development of economically viable biobutanol production [ 2, 3].

Two major challenges have been reported that typically limits the use of nanomaterials in cementitious materials.

Applying an approach to urban development based on a platform ecosystem might offer great opportunities, but will also be limited by the major challenges identified in this paper.

The poor targeted delivery of therapeutic genes into corneal cells in vivo is another major challenge that sharply limits clinical application of gene therapy to treat corneal disorders and diseases.