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As a country, we face major challenges because of the changing nature of our economy and society.
For the millions of blind people living in the United States, paying for something in cash can pose major challenges because there is no difference between the size and shape of a $1 or $100 bill.
However, the teaching and learning of concepts related to size and scale present major challenges because objects at certain scales are unable to be perceived by humans with the naked eye.
In particular, the provision of QoS for multimedia applications in a mobile environment imposes a series of major challenges because of the unreliable wireless channels and the mobility of mobile devices.
"One of the major challenges because we're growing so rapidly is that we've become the target of penny stock hustlers," said Steve DeAngelo, executive director of Oakland dispensary Harborside Health Center.
The pharmaceutical industry and the healthcare system are facing major challenges because of high failure rates of drugs, as reported, e.g., for cancer ("High attrition rates-where are we going wrong?" 69.
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This is a major challenge because in the vast majority of cases, we do not know what the true positives and negatives are.
Clinical trials, however, have become a major challenge because of issues with trial endpoints.
Anastomotic leakage in colorectal surgery remains a major challenge because of its early and late consequences.
Structure determination of multidomain proteins remains a major challenge because of their dynamic and heterogeneous nature.
The oral delivery of hydrophobic drugs presents a major challenge because of the low aqueous solubility of such compounds.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com