Sentence examples for major challenge given from inspiring English sources

It's a major challenge given obstacles surrounding oxygen and nutrient supply to the tissue.

But even with a sympathetic ear in the White House, getting Congress to agree to more visas could present a major challenge given the probability that, in a recession, public sentiment will be heightened that foreigners are taking Americans' jobs.

Generating fully mature adult cells will likely remain a major challenge, given the inherent biology of stem cells.

Ministers have long said they want to limit the amount of time kids can play games — although achieving that outcome is clearly a major challenge, given the popularity of video games and the proliferation of devices from which they can be accessed.

In general, an effective vaccination of newborns represents a major challenge; given the fact that the neonatal immune system is not fully matured and therefore not ready to respond to vaccination in an efficient manner.

However, activity is also a major challenge given the strain placed on this loaded implant.

One of the major challenges given by adding telaprevir or boceprevir to pegylated interferon combined with ribavirin is the addition of the toxicities given by these drugs to the engaging series of side effects given by the standard of care.

The efficient design and operation of supply chains with return flows represent a major optimization challenge, given the high number of factors involved and their intricate interactions.

Others, however, are warning that the deficit — even if it looks manageable over the next decade — still remains a major long-term challenge, given that rising health care spending on the elderly and debt service payments are projected to eat up a bigger and bigger portion of the budget as the baby boom generation enters retirement.

In addition, the issue of unwanted pregnancies, which is a major public health challenge given that the unmet need for family planning is still high and there is little or no access to safe abortion methods, was probably a frequent problem at the time of Mary.

Protection of water resources is a major challenge today, given that territory occupation and land use are continuously increasing.