Sentence examples for major cellular source from inspiring English sources

Antigen-presenting cells are the major cellular source of both proteins, and IL-27 has been shown to engage signaling via a heterodimer of the two transmembrane receptors WSX-1 and gp130.

Past studies have used predominantly synovial fibroblasts in culture as a model system for the regulation of collagenase production, but the major cellular source of the enzyme in vivo has not been determined.

Because mitochondrial dysfunction has been shown to play a major role in hypoxia-mediated injury and mitochondria are the major cellular source of ROS, there is considerable interest in targeting antioxidants to mitochondria [152].

Our observations indicate that T-zone FRCs also constitute a major cellular source of IL-33 in secondary lymphoid organs.

While supporting keratinocyte expression of FLG2 as the major cellular source [40], our data are inconsistent with their conclusion that FLG2 expression is restricted to the epidermis.

This observation coincided with the observation that FLG2 is only expressed in the uppermost epidermal layers of healthy skin (see below), supporting the idea that terminally differentiating keratinocytes represent the major cellular source of FLG2 in the skin.

Mitochondria are major cellular sources of hydrogen peroxide (H2O2), the production of which is modulated by oxygen availability and the mitochondrial energy state.

Mitochondria are major cellular sources of H2O2, the production of which is modulated by the mitochondrial energy state and generation of nitric oxide [7].

We focused on CD4+ T cells and γδ T cells, as these cells are believed to be the major cellular sources of IL-17 during lung bacterial infection [13], [16].

The major cellular sources of MMPs are macrophages and neutrophils.

The question arises, however, as to what are the major cellular sources of TF in sepsis?