Sentence examples for major cellular defense from inspiring English sources

The mitochondrial MnSOD therefore represents a major cellular defense against oxidative stress.

Antioxidant enzymes constitute one of the major cellular defense mechanisms against various oxidative insults [ 54].

HSPs represent a major cellular defense against the proteotoxic stress that is characteristic of age-related neurodegenerative disorders.

First, SOD-1 represents a major cellular defense against superoxide anion and peroxynitrite formation in endothelial cells.

I discovered the base excision-repair pathway, the major cellular defense against endogenous DNA damage [46 57].

The antioxidant Nrf2, which functions to protect normal cells from numerous damaging oxidative conditions, has been considered to be a major cellular defense mechanism.

The major cellular defenses against ROS include superoxide dismutases (SODs) and catalase [ 16, 17].

It has been shown to metabolize 4-hydroxynonenal (4-HNE) with high catalytic efficiency through its conjugation to glutathione (GSH) and has been suggested to be a major component of cellular defense against toxic electrophiles such as 4-HNE generated during LPO.

One major mechanism for cellular defense against oxidative stress is activation of the Nrf2-antioxidant response element signaling pathway.

Although HO-1 is known initially for its role in heme catabolism, HO-1 has become increasingly recognized that HO-1 expression exerts a major role in cellular defense mechanisms [ 10, 11].

As the glyoxalase system plays a major role in cellular defense against glycative and oxidative stress (Thornalley, 1993), its rate-limiting enzyme, GLO1, is a key enzyme that diverts MG from glycation reactions (Thornalley, 2003).