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HSCs are the major cells that produce CVI in the liver [87].
The major cells that carry out these functions are hepatocytes.
Postmitotic CNS neurons are the major cells that express PDGF-B ligand.
Given that RASFs were one of the major cells that express RANKL [ 23], here, RASFs were stimulated with IL-6 to induce RANKL expression.
In accordance to this, the osteocytes have been recognized as major cells that orchestrate bone remodeling through several molecular mechanisms [ 5] and recent studies are trying to elucidate the role of these cells in CKD-MBD pathophysiology [ 6].
Additionally, CD1a+ dendritic cells did not correlate with the other major cells that have been found to be important in COPD (macrophages, CD4 T cells and B cells). 3 22 23 This also implies that Lactobacillus may not directly impact these cells in disease.
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As discussed above, neutrophils are the major effector cells that lead to early graft loss in islet transplantation.
While DCs are the major stromal cells that perform negative selection at the cortical- medullary junction (CMJ) and in the medulla, TECs can also contribute to this process [9].
Macrophages are major immune cells that play an important role in the inflammatory response.
We replicated both of these findings in human lung fibroblasts, which are the major interstitial cells that maintain tissue structural integrity by sculpting the connective tissue.
A majority of these gene products target either cellular machineries that present viral antigens to major effector cells with specific immunity (CD8 T cells, CD4 T cells and natural killer (NK) T cells) or molecules that contribute to immune recognition by major effector cells that contribute to innate immunity (NK cells).
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