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Integrins, the major cell surface receptors mediating cell extracellular matrix (ECM) adhesion, are central to the basic physiology underlying all multicellular organisms.
For example, slpA gene encoding a major cell surface protein that forms a paracrystalline array in C. difficile contains a conserved region and a variable region [16] [18].
However, we did not observe that blocking the major cell surface protein (VSG) resulted in significant upregulation of procyclin, either at the RNA or the protein level (Fig. S7).
Other interesting genes identified within this cluster are FCER1G (1q23), encoding the high-affinity IgE receptor gamma subunit, TRAα, encoding the T-cell alpha locus, and THY1, encoding a major cell surface glycoprotein characteristic for T-cells (Figure 2 and Supplementary Table S1).
Egp34 is a major cell surface component of HT-29 cells (10 6) molecules per cell).
Gal f is also a major cell surface virulence factor in several human protozoan parasites.
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Filamentous hemagglutinin (FHA) is a major cell surface-associated adhesin that attaches to the host ciliary epithelial cells and is a virulence determinant [ 69, 70].
For example, TLRs 2, 4 and 5 are the major cell-surface sensors of bacterial lipopeptides, lipopolysaccharides (LPS) and flagellins, respectively, while TLRs 3, 7, 8 and 9 detect nucleic acid motifs [3].
CD44, which is one of major cell-surface receptors of HA, was detected in each cell line.
All CD44 isoforms contain a hyaluronic acid (HA -binding site in tHA -bindingellular domain, which sitees as the major cell-surface receptor for HA (Underhinl, 1992).
In general, to evade CAMP-mediated killinGram-negativeive and Gram-positive bacteria have evolved similar strategies to neutralize the net negative charge of major cell-surface molecules.
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