Sentence examples for major cell compartment from inspiring English sources

Furthermore, mitochondria are considered a major cell compartment relevant to possible nanoparticle toxicity [ 10].

Although CD8+ T-cell is the major cell compartment targeted by TGF-β antagonism, precise mechanisms whereby ALK5 inhibitors enhance anti-tumour cytotoxic T-lymphocyte (CTL) activity remain largely unknown.

We therefore determined whether oxLDL regulates Rcan1 expression in the major cell compartments present in the plaque.

The major cell compartments contribute to the age-related signaling pathways to a similar extent, with the exception of the Golgi apparatus.

Therefore, any differences observed in subsequent analyses were not a result of differences within these two major CD3+ cell compartments.

Tfh cells in lymph nodes (LNs) are PD-1 positive and serve as the major CD4+ T cell compartment for HIV-1 infection, replication, and production (Perreau et al., 2013).

Phenotypic analysis of various lymphoid organs (spleen, mesenteric, pancreatic lymph nodes) did not reveal any major modification of the T cell compartment as compared to untreated NOD mice (data not shown).

The upregulation of the TNFRSF11A_Δ7,8,9 variant observed in breast cancer tissues may reflect either major changes in the mammary cell compartment at the molecular level [ 4, 39] and/or changes in the tumor microenvironment, such as immune cell infiltration (T cells, macrophages, and so on) [ 39], occurring from early stages of breast tumorigenesis.

These effects depend on ARF6-stimulated cholesterol efflux out of the endosomal recycling compartment, a major cell repository for free cholesterol.

The fibroblast is a major cell type of the stromal compartment and is intimately involved in orchestrating the stromal half of the dialog with the epithelium in maintaining tissue homeostasis [ 8, 9].

These data demonstrate that Rcan1 expression in the haematopoietic cell compartment plays a major role in atherosclerosis progression.