Furthermore, our data evidenced that liver malondialdehyde levels were not significantly changed between both groups, indicating that potential changes in overall ROS production and lipid peroxidation were not a major cause to explain differences in tumor progression.
In 2006, we identified loss-of-function mutations in the progranulin gene (GRN) as a major cause of familial FTLD-U, explaining 25% of FTLD-U patients worldwide (Baker et al., 2006; Cruts et al., 2006; Gass et al., 2006).
Influtrol (a word I will be explaining) is a major cause.
Literature in strategic management identifies managerial hubris as a major cause of adverse firm performance, especially in explaining the failure of major strategic moves, such as mergers and acquisitions, or decreases in firm profitability (Roll 1986; Jiang et al. 2011).
In northern Tanzania, maternal social demographic factors are explained to be the major cause of excess neonatal mortality [ 9, 10].
Since heart disease is the major cause of death in both countries, how can one explain the difference in heart disease mortality rates?
Currently leading working theory explains plaques and tangles described above as the major cause of cell death and tissue loss found in an AD brain, though the theory is yet to be indisputably confirmed.
While geometric miss might partially explain the results, it is not the likely a major cause of their findings.
Further work investigating these pathways may help explain the vulnerability to superadded infection which is a major cause of poor clinical outcome in this population.
But most studies were unable to state the major cause of high plasma levels of sVCAM-1, which could be either explained by increased production or decreased clearance.
