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Dravet syndrome is a rare and catastrophic form of intractable epilepsy that begins in infancy, and SCN1A is well established as the major causal gene for this disease.
The major causal gene for ADCL is the elastin gene (ELN; MIM #123700), while one tandem duplication in the fibulin-5 gene (FBLN5; MIM#614434) has been described as well.
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Iw2 is one of the major causal genes related to variation in glaucousness among hexaploid wheat.
Major causal genes known to induce NSCLC include EGFR and KRAS.
In this article, we discuss major causal genes of lung cancers and intracellular signaling pathways involving those genes, and review studies on origin and stem cells of lung cancers, as well as the possibility of developing molecularly targeted therapies based on these studies.
Driver drowsiness has been implicated as a major causal factor in road accidents.
Excessive speed constitutes a major causal factor for these car accidents.
Nevertheless, disturbance is thought to be a major causal factor for stochastic processes.
Infectious disease is a major causal factor in the demography of human, plant and animal populations.
Smoking is considered as the major causal factor of chronic obstructive pulmonary disease (COPD).
Fusarium mangiferae is a major causal agent of mango malformation disease (MMD) worldwide.
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