Another key feature of the Cryptococcus HOG pathway is its involvement in production of two major virulence factors, capsule and melanin, and sexual differentiation [5], [6], [8].
We utilised a series of Klebsiella pneumoniae mutants in which the two major polysaccharide layers, capsule and lipopolysaccharide (LPS), were absent or truncated, to investigate the ability of these layers to protect against innate immune mechanisms and to associate with eukaryotic cells.
"We aren't tracking any major issues with the capsule.
Collagen type VI is one of the major components of the capsule of the pericellular matrix.
The serotype of a Streptococcus pneumoniae bacterium is designated according to the organism's polysaccharide capsule, its major virulence factor.
Pathogenic mycobacteria are surrounded by a non-covalently bound capsule, whose major carbohydrate constituent is a glycogen like α-glucan.
HaeBPF, a strain of nontypeable H. influenzae (NTHI), lacks genes encoding the polysaccharide capsule, a major virulence determinant of invasive H. influenzae.
Defects in antibody responses are seen in immunocompromised individuals, with B cell repertoire observed in both mouse and human in response to glucuronoxylomannan, a major constituent of cryptococcal capsule, being depleted in HIV infection (Pirofski, 2001).
One is the extracellular α-glucan, a glycogen-like polymer that is a major component of the capsule that surrounds the bacterial cell and participates in pathogenesis by serving to evade the immune response of the host [14].
The polysaccharide capsule is a major pathogenicity factor in pneumococci, and antibodies directed against it represent a major defense mechanism against this pathogen.
