It is not a little discomfort, as some might suspect, but a major burden on a person's psychological well-being.
He has argued that their responsibilities overlap and that they are a major burden on government spending.
"However, it is a major burden on M.L.S. because M.L.S. is not suited to have players gone for long periods of time.
The jump in commodity prices this year became a major burden on livestock producers and other food industry groups, which began campaigning for relief.
Not breastfeeding creates a major burden on the world economy as well, costing $302bn£210bnbn) globally in lost earnings, the authors found.
The influx of people has placed a major burden on the provision of such services as education, health and sanitation, water, and electricity.
Though he had 110 clients and nine employees and expected $3 million in billings in 2000, Mr. Smith said the court's verdict placed a "major burden" on his company and business tapered off.
The debate comes as student-loan debt, like mortgage debt, has become a major burden on households: In 2010, student-loan debt surpassed credit-card debt for the first time.
In the case of Texas, HB2 was upheld by the fifth circuit court of appeals even though it would place a major burden on the reproductive rights of women outside of a handful of urban centers, and despite the fact that the law has no plausible connection to protecting a woman's health.
The acute respiratory distress syndrome (ARDS) remains a major burden on intensive care units (ICU) worldwide.
Diseases related to contamination of drinking-water constitute a major burden on human health.
