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Discover Ludwig"major burden" is perfectly correct and usable in written English.
You can use it when referring to an obligation that is difficult to bear, especially mentally or emotionally. For example: "The major burden of taking care of her ailing parents was taking a toll on her health."
Exact(60)
It's also a major burden.
For many, shifting to a different career to avoid it would be a major burden.
Hepatocellular carcinoma (HCC) is a major burden on health-care systems worldwide.
Pesticides are a major burden for stream ecosystems in the central European cultivated landscape.
The prognosis for survival is good, but morbidity after the syndrome is a major burden.
Anxiety disorders are highly prevalent mental disorders that constitute a major burden on patients and society.
Still, he added, "It could have been a major burden if it had lasted longer".
It is not a little discomfort, as some might suspect, but a major burden on a person's psychological well-being.
Skin injuries affect millions of people around the world and represent a major burden in the healthcare sector.
Community-acquired pneumonia (CAP) causes a major burden to the health care system among children under-5 years worldwide.
Infectious diseases cause millions of deaths worldwide each year and are a major burden for economies, especially in underdeveloped countries.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com