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This was a major breakthrough.
"It was a major breakthrough".
A major breakthrough in gene therapy.
Nussenzweig's next major breakthrough came in 1979.
Mantell's realisation was a major breakthrough.
On verge of major breakthrough vis-à-vis choreography!
The machine represents a major breakthrough in costs.
"That was a major breakthrough in the profession," she said.
He added, "Do not expect any major breakthrough".
The identity of the Australian was the second major breakthrough.
"It's early days to portray this as a major breakthrough.
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