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The nAChR family consists of acetylcholine-gated channels that are formed as pentameric arrangement of homogeneous (α7, α8, α9) or heterogeneous (e.g., α4β2, α2β2) subunit combinations, of which the α4β2 AchRs represent the major brain subtype.
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structural connectivity; tracing the major brain white matter pathways.
For instance in the city of Sao Paulo, the major subtypes are subtype B (79%–88%) and subtype F (4%–11%) [4], [5].
No increasing trend in risks for two major subtypes of brain cancer, astrocytoma and PNETs, was observed by the increasing exposure index level (Table 6).
Kozlenkov, A. et al. Substantial DNA methylation differences between two major neuronal subtypes in human brain.
The major pathological subtype, accounting for approximately 50% of FTLD population, is FTLD-TDP where patients have brain inclusions of transactive response DNA-binding protein of 43 kDa (TDP-43) [ 15, 16].
Primary brain lymphomas (PBL) were distinguished from non-PBLs, and non-PBLs were classified, when possible, by major histological subtype (i.e. diffuse large B-cell lymphomas, Burkitt lymphomas or other) using the World Health Organisation classification of lymphoid neoplasms (Jaffe et al, 2001).
Hepatocellualr carcinoma (HCC) represents a major histological subtype of liver cancers.
Two major subtypes exist in the brain, those comprised of α4β2 and those comprised of α7 subunits [1], [2].
Clinical information and results from brain imaging were used to distinguish between major stroke subtypes, with excellent agreement between observers.
Although the grey matter of the Ptbp2 mutant brain appears largely normal in its overall patterning and the specification of major neuronal subtypes, examination of Nissl stained coronal sections revealed some white matter defects.
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