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Although almost all of the AAA+ ATPase genes that were examined are expressed at some level, approximately half of the genes are expressed at or below the 20th percentile with only six AAA+ ATPase genes showing expression at high levels across the major brain regions (Figure 7).
An initial psychophysiological interaction (PPI) analysis used an unconstrained model-free approach to compare the mode of functional connectivity for the processing of care or justice moral issues with seed regions confined to the three major brain regions comprising the putative moral cognitive neural network.
During neurulation, the ectoderm gives rise to the neuroectoderm in the form of a neural plate, which subsequently folds to generate the neural tube, composed of a single layer of neuroepithelial cells or neural stem cells (NSCs), where a series of ring-like constrictions mark the boundaries between the primordia of the major brain regions [3] [4].
At E12.5 the major brain regions are recognizable by specific gene expression (Shimamura et al., 1995).
The gene is expressed in neurons of all major brain regions.
Finally, we found that none of the volumes of the six major brain regions were significantly associated with head shape (online Additional file 1: S1 and Table S1).
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However, the function of MeCP2 in the striatum, a major brain region involved in motor control and executive cognitive functions, has yet to be studied.
Of particular relevance to adolescent social stress, both executive function ability and its major associated brain region, the prefrontal cortex (PFC), continue to mature during the adolescent period [ 10].
Once the TiO2 NPs were transported into the brain regions, major cells in the CNS, including the neurons and the glial cells, would be affected by NPs.
Several studies reported increased FA and decreased MD values from childhood into adulthood in several major fiber tracts and brain regions (Faria et al. 2010; Tamnes et al. 2010; Westlye et al. 2010; Lebel and Beaulieu 2011).
Furthermore, the connectivity maps of all stimulation conditions (except L-D) were mainly distributed in the bilateral insula, inferior parietal cortex, and subregions of the secondary somatosensory cortex (subregions OP1 OP4), suggesting a major role of these brain regions in the observed insular connectivity network.
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