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Discover Ludwig"major blow" is a correct and usable phrase in written English.
You would use it to describe a large, damaging event or setback. For example, "The company suffered a major blow after the stock market crashed."
Exact(60)
"To lose Snodgrass was a major blow.
This news is a major blow.
Amar'e's injury is obviously a major blow.
Enron was a major blow, too.
Days-at-sea restrictions a major blow for Scots fleet.
The news is a major blow to Labour.
"That would be a major blow to our industry".
The Benin forward's absence will come as a major blow.
The loss of Evans could be a major blow.
Monday's regulatory move deals ZTE a major blow.
Its fall is, however, another major blow to the rebels.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com