Two weeks later, he had a major bleeding stroke.
MAIN OUTCOME MEASURES: In-hospital events were myocardial infarction, arrhythmia, congestive heart failure or shock, major bleeding, stroke or death.
Outcomes including death, myocardial infarction (MI), revascularization, major bleeding, stroke, death or MI, death or MI or revascularization, and death or MI or stroke were compared with estimated cumulative incidence rates with inverse probability weighted estimators and Cox proportional hazards ratios.The DES were implanted in 217,675 patients and BMS were implanted in 45,025.
Adverse events are: major bleeding, strokes, severe hypotension, allergies, re-thrombosis and reperfusion syndrome.
No studies in the current review reported major bleeds, stroke or bruising.
The study, called the Cabana trial, found that the procedure was no more effective than much cheaper medications at reducing mortality, cardiac arrest, major bleeding and stroke.
Main outcome measures of interest included 30-day death and in-hospital cardiogenic shock, major bleeding, and stroke.
Take-home point: Fibrinolytic therapy might prevent hemodynamic decompensation in patients with intermediate-risk pulmonary embolism, but this benefit comes at the cost of significantly higher major bleeding and stroke.
Outcomes after major bleeding, including stroke or non-central nervous system embolism (4.7% rivaroxaban vs. 5.4% warfarin; HR 0.89; 95% CI 0.42-1.88) all-causeause death (20.4% rivaroxaban vs. 26.1% warfarin; HR 0.69, 95% CI 0.46-1.04) were similar in patients treated with rivaroxaban and warfarin (interaction P = 0.51 and 0.11).
METHOD AND RESULTS: We performed a retrospective analysis of 94,108 STEMI patients from seven clinical trials evaluating various reperfusion strategies to study the relationship and prognostic importance of height, weight, body mass index (BMI), and body surface area (BSA) with 30-day death and in-hospital cardiogenic shock, major bleeding, and stroke.
The consequences of poor INR control are serious and include increased risk for death, myocardial infarction, major bleeding, and stroke [ 5].
