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In patients with major bleeding, requirements for fibrinogen are larger than for any other haemostatic protein [ 2].
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We designed an observational prospective study to evaluate early complications after cardiac transplantation, focusing on major bleeding and transfusion requirements.
No major bleeding episodes requiring blood transfusions were seen.
In contrast, major bleeding, leading to a requirement for transfusion of at least one unit of blood or occurring in a critical organ, occurred more frequently in the fondaparinux- than in the enoxaparin-treated group.
Major bleeding was defined as any bleeding requiring blood transfusion.
The overall frequency of major bleeding complications such as development of haematoma and requirement for transfusion or intervention was 6.8%.
Major bleeding was defined as any bleeding or vascular complication requiring additional therapy.
Major bleeding was defined uniformly across the studies (fatal bleeding, bleed into critical site, fall of ≥20 g/L haemoglobin, or requirement for transfusion of two or more units of blood), whereas non-major bleeding was defined heterogeneously.
Two weeks later, he had a major bleeding stroke.
Major bleeding is less frequent.
The safety outcomes were major bleeding, minor bleeding and death.
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