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Local rtPA infusion with, or without continuous heparin was successful for the majority of patients, and was associated with few major bleeding complications.
No major bleeding complications were documented.
Systemic anticoagulation with standard heparin, the most used, can lead to major bleeding complications.
Objectives: Report the safety profile and efficacy of fondaparinux (thrombotic and major bleeding complications) in patients with HIT and ARF during continuous renal replacement therapy (CRRT).
During treatment, major bleeding complications occurred in 2.8% of the patients in the LMWH arm versus 4% in the OAT arm: no statistically significant difference was observed (p = 0.31).
At 30 days, all patients were free of the primary clinical outcomes defined as a composite of death, myocardial infarction, or repeat target vessel revascularization, and there were no major bleeding complications.
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In this rather small study, including 121 patients only, 61 receiving rtPA, the authors did not observe any major bleeding complication, suggesting that lower dosage of thrombolytic treatment may have a significant hemodynamic impact without increasing the risk of major bleeding.
No patient suffered a major bleeding complication.
Major bleeding complication rates varied considerably among different agents.
However, the definition of major bleeding complication varied among the studies.
Conversely, the risk for major bleeding complication was 15% higher for rivaroxaban.
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