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Exact(6)
There was no significant difference in rates of major bleeding between the treatment arms (Table 1).
There was no mortality difference and no difference in major bleeding between the two study arms.
There was no significant difference in net clinical benefit (major vascular events plus major bleeding) between the two groups.
In the DM subgroup of the TRITON-TIMI-38 trial, there was no difference in major bleeding between prasugrel and clopidogrel treated patients, regardless DM treatment type [ 12].
The ENGAGE AF-TIMI 48 study found a statistically significantly reduced rate of major bleeding between the high-dose (2.75 %) and low-dose (1.61 %) edoxaban groups versus well-controlled warfarin (3.43 %; p < 0.001 for both groups) (Fig. 2b).
There was no significant difference in the rate of major bleeding between the nadroparin group (five events) and the placebo group (one event; P=0.12) (Klerk et al, 2005).
Similar(54)
There was no difference in major bleeding rates between the groups.
Bramham et al. reported thrombosed circuits in 2.2% of UFH and 0.7% of tinzaparin treated patients with major bleeding events between 0 and 0.26% [ 21].
There were no differences in major bleeding rates between ticagrelor and clopidogrel in a group of patients presumed to be at higher risk of bleeding (age of at least 75 years, weight of less than 60 kg, chronic kidney disease, aspirin dose of greater than 325 mg on the day of randomization, pre-randomization clopidogrel administration, or clopidogrel loading dose) [ 16].
Rates of any bleeding and major bleeding were similar between the study arms in both RE-COVER (Figure 2B) and RE-COVER II [20, 21].
The number of prophylactic and therapeutic transfusions and the incidence of minor and major bleeding were compared between the 2 groups.
Related(17)
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