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Major bleeding became the major barrier for clinicians to employ these therapies.
The potential impact that adherence could have on the risk of major bleeding became apparent when the results of the randomized controlled trial were stratified by time in therapeutic range [ 21].
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"Bleeding becomes an even bigger issue in real clinical practice".
Should accumulation of nadroparin occur, this becomes another risk factor for major bleeding in patients who already have an increased bleeding risk [3], [9].
Two weeks later, he had a major bleeding stroke.
Major bleeding is less frequent.
The safety outcomes were major bleeding, minor bleeding and death.
No major bleeding complications were documented.
The secondary safety outcomes include major bleeding, clinically relevant non-major bleeding, and overall survival rates.
A decrease in pneumothorax or major bleeding is observed.
Major bleeding in cirrhotic patients was associated with poor outcome.
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