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The stress response enzyme heme oxygenase 1 (HO-1) is expressed ubiquitous in the body tissue and mediates, besides its major biological function of heme degradation, a variety of anti-inflammatory effects.
The breakthrough in development of biological agents for the treatment of RA was to target the immune system, which was ascribed to new insight into the major biological function of TNF-α in joint inflammation and destruction.
All eligible individual biomarker assays were sorted according to their major biological function.
As a major biological function, they hydrophobize fungal spores and allow them to be easily dispersed and liberated [ 6– 8].
The major biological function of IL-18 seems to be linked to inducing type 1 responses and stimulating IFNγ production [ 35].
PlGF belongs to a family of vascular endothelial growth factors (VEGF) and the major biological function of PlGF is promoting angiogenesis through VEGF receptor-1 (VEGFR-1) signaling.
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To understand the functions of differentially expressed genes, functional GO enrichment analysis was executed in order to determine major biological functions of DEGs between the two treatment samples (JA and MeJA) (Additional file 16).
Studies have shown that people with the syndrome experience abnormalities in the central and autonomic nervous systems, the immune system, cognitive functions, the stress response pathways and other major biological functions.
Furthermore, these substitutes secreted adipokines and mediated β-adrenergic receptor-stimulated lipolysis, hence reproducing known major biological functions of white adipose tissue.
These results demonstrated the major biological functions of the genes expressed in the C. cladosporioides MD2 transcriptome.
These genes were involved in numerous major biological functions such as lipoprotein metabolism (LIPC, PCTP), inflammation (VNN1), peroxisomal β-oxidation (PEX11A), and ketogenesis (FGF21).
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