All three cytokines signal through heterodimeric specific receptors consisting of major binding and ligand-specific α chains, and a signalling subunit βc which is shared amongst all three receptors.
Interestingly, the data indicate that the Nter domain of the VIP and PACAP receptors is a major binding site, essential for the recognition of their respective ligands (Cao et al., 1998; Laburthe et al., 2007; Vaudry et al., 2009; Couvineau et al., 2010; Dejda et al., 2011).
Phenylalanine-glycine (FG) repeat motifs are found in about one-third of the nucleoporins, and they provide major binding or docking sites for soluble transport receptors.
We previously identified IgFLNa21 as the major binding site in FLNa for integrin adhesion receptors (Kiema et al, 2006).
Cell surface receptor interactions with their ligands often involve hydrophobic contact points which provides the major binding energy.
major binding saccharides.
The E2 sequence of Sindbis virus can be divided into extracellular domain (1 363 aa), penetration domain (364 392 aa) and intracellular tail region (393 423 aa), among which the extracellular domain is a major receptor-binding region important for virus entry and infectivity.
PI is linked to a major receptor binding site (Hundt and Schmidt, 1992) important in intracellular signalling and activation (Tissot et al, 1991).
There are only two known major classes of CP receptors: M6P-binding receptors (CI-MPR and CD-MPR) and Vps10p/sortilin.
When this vaccine moved into Phase I human trials, strong antibody responses were detected by enzyme-linked immunosorbent assay [63]; these antibodies could block viral E2 protein-binding CD81, a major entry receptor for HCV [63].
