Sentence examples for major binding protein from inspiring English sources

However, little is known regarding the effects of blood specimen processing time on measured levels of total and free IGF-I, and on IGFBP-3, the major binding protein.

In the present retrospective study, we measured the serum levels of IGF-I and IGBP-3, its major binding protein.

Insulin-like growth factor binding protein 3 is the major binding protein for insulin-like growth factors in the blood and also has IGF-independent apoptotic effects.

Concentrations of a major binding protein for IGF-1, IGF binding protein 3 (IGFBP-3), affect the bioavailability of IGF-1 (indicated by the molar ratio of IGF-1/IGFBP-3) and may also be independently associated with cancer risk.

Thereby, particularly liver macrophages are considered to be the major source of IGFBP-3 (Villafuerte et al. 1994), the major binding protein for circulating IGF forming a ternary binding complex comprising IGF, IGFBP and the acid-labile subunit (ALS).

As albumin is likely a major binding protein [ 11], the serum-albumin concentration was analyzed in all age-7 serum samples to allow adjustment for this possible source of variability.

As the name suggests, these include the major binding proteins of certain immunosuppressive drugs: cyclophilins for the cyclic peptide cyclosporin A and FK506-binding proteins for the macrolactones FK506 and rapamycin.

Consistent with a role of ZNF198 in transcriptional regulation, several well established transcriptional repressors, including LSD1, CoREST and HDAC1/2, are major binding proteins of ZNF198 in vivo.

This result indicates that LSD1, CoREST, and HDAC1/2 are major binding proteins of ZNF198 in human cells and confirms earlier findings that have demonstrated the interactions between the LCH complex and proteins containing MYM zinc fingers.

This hypothesis is indirectly supported by the finding that droloxifene 100 mg/day causes alterations in plasma levels of sex hormone binding globulin, insulin-like growth factor I and its major binding proteins, resembling what we see during treatment with tamoxifen, whereas droloxifene 40 mg/day exhibited only moderate effects [ 19- 23].

S-adenosyl L-homocysteine hydrolase was also shown to bind copper with high affinity and is indeed the major copper binding protein in mouse liver [89,90].