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As one of the major binding partners of AKAP5 is the RIIβ subunit of PKA we tested whether any of the well-studied RIIβ KO phenotypes might be recapitulated in the AKAP5 KO or D36 mutants.
Since sLex moieties are major binding partners of E-selectin, we further determined whether the binding of exE-selectin/Fc to metastatic breast cancer cells was dependant on tumor cell surface sLex moieties.
Similar(58)
Interestingly, FHL2 binds to β-integrin, which together with clathrin, a major binding partner of CALM, has been shown to be involved in endocytosis.
TEAD family transcription factors are the major binding partner of TAZ in the nucleus.
These bands were excised, digested by trypsin and analyzed by LC-MS/MS, resulting in the identification of HSP60 as the major binding partner of SIRT3.
Since syntaxin is a major binding partner of Munc18-1, wevaluateded whether syntaxin proteolysis has similar effects.
The larger molecular size peak fraction of β-catenin reflects β-catenin/α-catenin dimers, as this peak perfectly cofractionates with α-catenin (Fig. 2A), shRNA knock-down of α-catenin eliminates this size fraction of β-catenin (Fig. 2B & C), and α-catenin is the major binding partner of β-catenin in these cells (Fig. 2D).
We have previously reported that PACRG is the major binding partner of the MEIG1 protein.
Thus, MEIG1 is also the major binding partner of the PACRG protein.
FK506 binding protein 12 is a major binding partner for FK506 and rapamycin (Siekierka et al, 1989).
Although the major binding partner VPS34 stabilizes Beclin 1, the HECT ligase Nedd4 promotes its degradation by the proteasome.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com