Sentence examples for major binding partner from inspiring English sources

Interestingly, FHL2 binds to β-integrin, which together with clathrin, a major binding partner of CALM, has been shown to be involved in endocytosis.

The frequent detection of the ILK RhoT1 interaction in the cytoplasm and at FAs, irrespective of the colocalization of mitochondria (Supplementary Fig. 10), strongly suggests that "cytoplasmic RhoT1" is the major binding partner of ILK.

TEAD family transcription factors are the major binding partner of TAZ in the nucleus.

These bands were excised, digested by trypsin and analyzed by LC-MS/MS, resulting in the identification of HSP60 as the major binding partner of SIRT3.

Since syntaxin is a major binding partner of Munc18-1, wevaluateded whether syntaxin proteolysis has similar effects.

The larger molecular size peak fraction of β-catenin reflects β-catenin/α-catenin dimers, as this peak perfectly cofractionates with α-catenin (Fig. 2A), shRNA knock-down of α-catenin eliminates this size fraction of β-catenin (Fig. 2B & C), and α-catenin is the major binding partner of β-catenin in these cells (Fig. 2D).

Since sLex moieties are major binding partners of E-selectin, we further determined whether the binding of exE-selectin/Fc to metastatic breast cancer cells was dependant on tumor cell surface sLex moieties.

The major BRCA1 binding partner, BARD1, is also implicated in the prognosis of breast cancer41.

Also, OGT and HCF1 were characterized as major cellular binding partner of THAP1, a sequence-specific DNA binding factor (Mazars et al., 2010).

α-catenin is a major stoichiometric binding partner of cytosolic β-catenin [25], and its over-expression can antagonize β-catenin nuclear signaling activity through an incompletely defined mechanism [27], [28], [38].

A major SHP2 binding partner is Grb2-associated binder-1 (Gab1), which becomes tyrosine-phosphorylated upon growth factor stimulation.