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The major basic salivary proline-rich proteins are encoded by PRB1, PRB2, PRB3 and PRB4 and contain multiple repeat domains of 20 or 21 amino acids [32] (supplemental Figure S2).
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In detail, the non-stimulated salivary glands at rest exhibit a basic blood circulation and a basic salivary flow.
Sensitization significantly increased major basic protein deposition in the lungs.
In saliva, Histatin 5, a human basic salivary peptide with strong fungicidal properties in vitro, is salt sensitive and exerts low activity at high salt conditions [ 25].
The sole C. quinquefasciatus sequence shown in Figure 7 (gi|170045863), the 41.9-kDa basic salivary protein, does not group significantly with any other sequence.
Although parathion had no effect on major basic protein deposition in nonsensitized animals, it significantly decreased major basic protein deposition in sensitized animals.
They occur in the major and minor salivary glands, whereof 80% of major salivary gland tumours are present in the parotid glands, and less than half of these tumours are malignant [ 3].
For instance, filtering and centrifugation techniques may remove major populations of salivary proteins leading to the formation of salivary pellicles which are not representative of those present in vivo.
On the other hands, MEC occurs frequently in the major salivary glands (51% of total malignant tumours in major salivary gland; Pinkston and Cole, 1999).
The vast majority of mucoepidermoid carcinomas arise within the major or minor salivary glands.
Mucoepidermoid carcinoma (MEC) is the most frequent malignant tumour that originates in the major and minor salivary glands, and represents about one third of all malignant salivary gland tumours (Spiro, 1986; Goode and El-Naggar, 2005; Ellis and Auclair, 2008).
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