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In order to immunostaining eosinophils, we used antibody to major basic protein as a marker.
To investigate the hypothesis that eosinophil major basic protein is released in high concentrations in the nasal mucus of patients with polypoid chronic rhinosinusitis.
Previously, PAPP-A was measured with polyclonal antibodies which were later shown to recognise also the pro-form of major basic protein (pro-MBP).
To assess the expression and cellular distribution of pregnancy-associated plasma protein-A (PAPP-A) and major basic protein (MBP) in human ovarian tissue during the menstrual cycle.
PURPOSE: Recurrent or persistent corneal erosions and ulcerations are typical complications of atopic keratoconjunctivitis. Toxic eosinophil granule proteins such as major basic protein (MBP) and eosinophil cationic protein (ECP) may be involved in this pathogenetic process.
Proteoglycan-2 or eosinophil granule major basic protein (mbp2) is a specific eosinophil marker [39].
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Wehling-Henricks, M. et al. Major basic protein-1 promotes fibrosis of dystrophic muscle and attenuates the cellular immune response in muscular dystrophy.
28 Eosinophils were localised in mouse and human tissues (Institutional Review Board approved) by eosinophil major basic protein-1 (MBP-1) and eosinophil peroxidase immunohistochemistry as previously described.
This Th2-dominated environment also induces the activation of eosinophils that promote muscle fibrosis through major basic protein-1-mediated processes [ 45].
In particular, genetic ablation of major basic protein-1 (MBP-1), a cytolytic protein expressed by eosinophils, caused an increase in the numbers of cytotoxic T cells in dystrophic muscle [ 50].
3 6 The ESGPs include four cationic proteins present in the eosinophil's large specific (secondary) granule known as major basic protein-1 (MBP1), eosinophil peroxidase (EPX), eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP).
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