To date, no research has addressed the major and difficult-to-answer question of the ideal treatment for an individual patient from the health services perspective, i.e. the treatment with the lowest cost of extra health gains.
In hindsight, we have to admit that we were quite slow in appreciating that Cryptosporidium infection in a renal transplant patient is a major, significant and difficult to treat, complication, rather than a temporary episode of diarrhoea with an unusual pathogen.
Obesity-related beliefs included believing obesity to be a major public health problem and difficult to treat (98.2% and 96.4%, respectively) and considering obesity to be a disease (85.5%).
It is so expensive and difficult to manufacture that major drug companies are not interested.
A major and difficult task is the design of clinical trials with a time to event endpoint.
The availability of Megasport Arena was a factor in a world where major venues in major cities are difficult to secure on such short notice.
A02-ST09 malsolso potentially have been reheated because the AHe and the ZHe ages overlap within the error range; such rapid and major cooling is difficult to explain by a denudation episode considering the general tectonic history of the NE Japan Arc since the middle Miocene.
Roger Federer is three wins from making more history here at Flushing Meadows, a sixth US Open title and an 18th major, and it is difficult to see even the unpredictable Gaël Monfils posing him many problems in the quarter-finals on Wednesday, although it will not be dull.
The long term plans of these and other major companies are difficult to piece out, since as we all know, the necessities of the user, and the capability of his devices, are changing faster every year.
We encountered some limitations, including the major difficult to have accurate financial hospital data and detailed information on the behavior of each agent within this complicated context.
