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During the 12-week followup, no death or major amputation occurred [ 35].
A first major amputation occurred in 38 patients (15.4%) during follow-up.
Patients with minor amputations were further followed up until 31 December 2009 and were included if a major amputation occurred.
Unsuccessful thrombolysis requiring conversion to open operation and/or immediate major amputation occurred after 56 episodes (17·6 per cent) in Uppsala and 94 episodes (21·9 per cent) in Malmö (P = 0·151).
Similar(56)
Despite percutaneous transluminal angioplasty or vascular surgery, major amputation occurs in about 13% of patients suffering from CLI [2], thereby emphasizing the crucial need for alternative efficient pharmacological treatments.
Due to poor outcomes of existing therapies, lower extremity amputation is a common complication, affecting 15% of diabetics with foot ulcers, with one major amputation occurring every 30 seconds worldwide and over 2500 limbs lost a day [ 2].
Complications associated with digital ulcers, such as infection requiring systemic antibiotics, gangrene and amputation occurred frequently in all major SSc subsets.
Follow-up ended if amputation occurred.
Digital gangrene or amputation occurred in 6.4% of patients.
These differences should be considered along with the finding that a significantly higher proportion of Burgess amputations occurred on the battlefield, while a higher proportion of Ertl amputations occurred at major military installations in Europe or America.
Thirty-seven tramputationsutatioccurredrred (1.2%).
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