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However, major amplification of MLK4 was identified in patients with triple-negative breast invasive carcinoma and the lack of targeted therapies in TNBC prompt us to investigate the role of MLK4 in this specific subtype of breast cancer.
The major amplification and dispersal of DUXY paralogs occurred after the gibbon and hominid lineages had diverged.
In addition, recent studies in humans vaccinated with VV showed a major amplification of CD8 cells at priming [15].
This data set has previously been analyzed to determine major amplification and deletion events using the RAE [13] and GISTIC [12] algorithms [7].
In normal mice on CR, there is a major amplification of the insulin signaling cascade, with increases in protein concentration and/or (insulin-stimulated) activation of almost all the cellular mediators of insulin action tested in the present study (summarized in Figure 7).
Culex species are the major amplification vectors of WNV in the United States (8, 9) and may also be vectors of WNV in Guadeloupe.
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Platzer et al. [11] analyzed four major amplifications of entire chromosomes or chromosome arms 7p, 8q, 13q, and 20q in liver metastases of colon cancer.
The major isothermal amplification techniques currently utilised include: Nucleic Acid Sequence based Amplification (NASBA) [ 42], Transcription Mediated Amplification (TMA) [ 43], Loop-Mediated Isothermal Amplification (LAMP) [ 44], Helicase Dependant Amplification (HDA) [ 45], Rolling Circle Amplification (RCA) [ 46] and Strand Displacement Amplification (SDA) [ 47].
Since the 1990s three major whole genome amplification techniques including primer extension pre-amplification (PEP) [ 48], degenerate oligonucleotide primed (DOP) PCR [ 49] and multiple displacement amplification (MDA) have been developed to address the problem of limiting amounts of DNA samples.
Two major variables: the amplification process will change the abundance of the transcripts and low signal strength may results from inefficient probes.
This assay comprised of two major steps: (i) Amplification of internal control sequences and genomic target sequences (ii) melting curve detection by florescence measurement at 640 nm.
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