Sentence examples for major alterations that from inspiring English sources
He was the architect of the major alterations that produced the 2002 debacle.
Such mutations represent one of the major alterations that might explain the different histological types found in ovarian cancers.
Using this strategy, Rmaps harboring major alterations that preclude alignment to the reference were gradually incorporated into the consensus map, extending it into regions that contain more complex rearrangements.
Similarly, array comparative genome hybridization is designed to get an overview of major genomic alterations that can be fine-tuned with technologies such as next-generation sequencing.
Using four biological replicates, we have identified all of the major transcriptional alterations that occur during acclimation using a 2-fold change cut-off threshold.
The recent characterization of the human cancer genome (Cancer Genome Atlas Research Network, 2008; http://cancergenome.nih.gov/) and transcriptome of GBM has provided a high-resolution picture that has revealed the major gene alterations that may drive disease pathogenesis and biology.
Since KDM1A overexpression was detected in all molecular subgroups of human medulloblastomas, transgenic mice with activating mutations in the sonic hedgehog pathway are likely to be suitable mouse models to preclinically test KDM1A inhibitors, even though these models mimic major genetic alterations that occur in only approximately 25% of medulloblastomas [ 37].
Here we demonstrate that abolished intestinal peptide transport also leads to major metabolic alterations that culminate in a two fold increase in total body fat content.
First, the "sandwich RNA-inhibition strategy" uses multiple agents to focus on a major molecular alteration that is clearly linked to CLL pathogenesis.
Major trauma induces metabolic alterations that contribute to the systemic immune suppression in severely injured patients and increase the risk of infection and posttraumatic organ failure.
MSGs and SRs were not randomly associated within tumors, delineating two major pathways of chromosome alterations that consisted of either chromosome gains by MSG or chromosomal losses by both MSG and SR.
