Sentence examples for major alterations over from inspiring English sources

In order to identify a given set of genes that exhibited major alterations over time, a model-based clustering method [ 30] was employed, and the genes in the cluster were considered as differentially expressed over the time period.

The building was subsequently given landmark status, protecting it against major alterations, and a court battle over that designation dragged on until it was upheld by the Supreme Court in 1991.

Importantly, recombination in the BTS accounted for two of three interclade recombination events and may contribute more heavily to major alterations in the TLO repertoire over time compared to recombination at other points.

Exposure to high concentrations of CsA (15 μM) led to major alterations of the biodistribution of CsA over time.

Because of their retention over the millennia, with no major alterations in the protein fold or catalytic mechanism, Prxs can be seen as being integral to the existence of life on Earth.

Over recent years, there have been major alterations in dietary habits, with growing transition from home-made to eaten-out foods and pre-prepared meals (including 'heat-and-eat' foods, fast foods or takeaways).

Acclimation of PSII thermotolerance thus occurs over a relatively long timeframe and includes an apparent lag phase, indicating that major alterations to the cellular metabolic machinery are required, but is essentially complete within 480 minutes.

Additionally there are multiple reasons for creatinine change over time, including both progression and remission of kidney disease, measurement error, use of medications affecting creatinine secretion, altered creatinine generation due to body composition changes, and major alterations in dietary intake.

maintains that both major parties need major alterations.

Sometimes landmark designation is awarded after major alterations.

Major alterations in his professional life and his technique were required.